Dirty throttle bodies/plates mostly impact idle control, where idle speeds might be erratic or higher than nominal, idle stumbles or surges when A/C compressor cycles, headlights turned on, etc. It can also confuse the PCM with higher than normal load calculations based on higher than normal throttle opening %, which can lead to fuel trim offsets at idle. The fuel trim offset can cause off-idle initial "tip-in" stumbles, where the PCM scrambles to correct fuel trims.
So, yes, good to scrub the first 3" of the throttle body and the throttle plate every 50k miles, plus or minus, with a throttle body cleaner. Carb cleaner may be OK, but I don't know if Honda uses a solvent vulnerable TB coating, like Ford and others used/use.