I had the same issue on 2018 EX-L. We purchased the Pilot used with 58k miles. Transmission system problem flashed on display when I set cruise control at 65 mph. P0741 diagnostic code, just like you had. Dealer changed out ATF, said it's fixed. Problem repeated about one hour into a 3 hour drive. Again, at 65 mph in cruise. I could see by the wavering tach needle, that the torque converter lockup was slipping at 65 mph. Honda replaced the torque converter under warranty.Just got it back. Part came in this morning and transmission replaced today. Paperwork said the code was P0741. Test drove it for awhile. Seems to drive the same as before! Hopefully it’s the last issue we have!
I am convinced that this is the result of the VCM system, which plays the lockup clutch back and forth as it tries to smooth out the vibrations of VCM. Excessive wear and premature failure of the torque converter lockup clutch is the result. At 58k miles, my torque converter was shot. By the way, my service rep had to delay repair almost 2 weeks, because Honda has a nationwide shortage of torque converters. Maybe because VCM is eating them up?
I just ordered an S-VCM unit, so I can disable this function. Just sayin--