I have over 321,000 miles on my 2006 Pilot. Still running good with the original motor and original transmission. I do oil changes (actually my automotive shop does) every 7000 miles and a transmission flush every 60,000. Brakes, spark plugs and timing belt kit every 100,000. Valve adjustment at 200,000. I use a quart of oil about every 4000 miles. Gas mileage has decreased somewhat over time and mileage. I still get 19-20 mpg. I used to get 23-24 when I had less than 100,000 miles on it.